1. Pak J Pharm Sci. 2015 Sep;28(5):1723-30. Effects of metformin plus gliclazide versus metformin plus glimepiride on cardiovascular risk factors in patients with type 2 diabetes mellitus. Combined use of glimepiride and metformin may increase the potential for hypoglycemia. Patients should be informed about the importance to dietary instructions, of a regular exercise program, and. When switching from combination therapy of glimepiride plus metformin as separate tablets, Amaryl M S.R. should be administered on the basis Of dosage currently being taken. We examined the efficacy of rosiglitazone when added to a therapeutic regimen of glimepiride and metformin in type 2 diabetic patients. A total of 38 Greek diabetic patients inadequately controlled on maximum doses of glimepiride (6 mg/day) and metformin (2,550 mg/day) were given rosiglitazone. After 24 weeks, the overall mean treatment difference in HbA 1c between Glimepiride tablets and metformin was 0.2%, favoring metformin (95% confidence interval -0.3% to + 0.6%). Based on these results, the trial did not meet its primary objective of showing a similar reduction in HbA 1c with Glimepiride tablets compared to metformin. Aims/Introduction. To compare the efficacy and safety of early combination therapy with glimepiride/metformin to metformin uptitration in reducing glycated hemoglobin (HbA1c) levels in Korean type 2 diabetic patients inadequately controlled on low-dose metformin monotherapy. Drugsupdate.com is up for sale. To own one of the most recognized online brands by doctors in India with millions of visitors - click here. glimepiride with that of metformin and sitagliptin in type 2 diabetes mellitus with respect to glycemic targets Mohammad Anjoom 1 , Shaktibala Dutta 1 , Mirza Atif Beg 1 , Amit Varma 2 , Shalu Bawa 1 , Ravi Kant 2 Le glimépiride agit en augmentant la production d'insuline par le pancréas et en aidant l'organisme à utiliser l'insuline de manière plus efficace. Sandoz Glimepiride: Le glimépiride appartient à la classe des médicaments appelés hypoglycémiants oraux. Glimepiride + Metformin Adverse Reactions / Glimepiride + Metformin Side Effects. Diarrhoea, vomiting, metallic taste, rash, isolated transaminase elevations.